Infectivity of Post-Kala-azar Dermal Leishmaniasis Patients to Sand Flies: Revisiting a Proof of Concept in the Context of the Kala-azar Elimination Program in the Indian Subcontinent
نویسندگان
چکیده
We compared xenodiagnosis with quantitative polymerase chain reaction in skin biopsies from 3 patients with maculopapular or nodular post-kala-azar dermal leishmaniasis (PKDL). All patients infected sand flies. Parasite loads in skin varied from 1428 to 63 058 parasites per microgram. PKDL detection and treatment are important missing components of the kala-azar elimination program.
منابع مشابه
Of Cattle, Sand Flies and Men: A Systematic Review of Risk Factor Analyses for South Asian Visceral Leishmaniasis and Implications for Elimination
BACKGROUND Studies performed over the past decade have identified fairly consistent epidemiological patterns of risk factors for visceral leishmaniasis (VL) in the Indian subcontinent. METHODS AND PRINCIPAL FINDINGS To inform the current regional VL elimination effort and identify key gaps in knowledge, we performed a systematic review of the literature, with a special emphasis on data regard...
متن کاملPost-Kala-Azar Dermal Leishmaniasis in Mymensingh, Bangladesh
the patient had visceral leishmaniasis (kala-azar), successfully treated with 30 intramuscular injections of sodium stibogluconate (SSG). Polymerase chain reaction showed Leishmania donovani DNA in a buffy coat specimen. Post-kala-azar dermal leishmaniasis (PKDL) is a chronic skin rash usually seen in apparently cured kala-azar patients in East Africa and South Asia. In the Indian subcontinent,...
متن کاملleishmaniasis-current BurDen anD trenDs
Natural transmission of leishmaniasis is carried out by female sand flies. VL is a systemic disease characterised by prolonged fever, splenomegaly, hepatomegaly, weight loss, progressive anaemia, pancytopenia, and is complicated by serious infections. After recovery, some patients (50% in Sudan and 1 3% in India) develop post kala-azar dermal leishmaniasis (PKDL) characterised by depigmented ma...
متن کاملChallenges in the diagnosis of post kala-azar dermal leishmaniasis.
Post kala-azar dermal leishmaniasis (PKDL) is a dermatosis that occurs as a sequel of visceral leishmaniasis (VL). Elimination of VL requires detection and treatment of PKDL, necessarily because of its capacity to serve as a reservoir for the causative parasite, Leishmania donovani. Diagnosis of PKDL presents a challenge due to low parasite burden in the lesions. In this article we have reviewe...
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1. Rogers L. The epidemic malarial fever of Assam, or kala-azar, successfully eradicated from tea garden lines. Br Med J. 1898; 2:891–2. 2. Price JD, Rogers L. The uniform success of segregation measures in eradicating Kala-azar from Assam tea gardens: it is bearing on the probable mode of infection. BMJ. 1914;1:285–9. http://dx.doi. org/10.1136/bmj.1.2771.285 3. Kaul SM, Sharma RS, Borgohain B...
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